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Operational Research

Dachshunds and Data: coming together at the OR Society Conference #OR56

Sophie Carr (Bays Consulting) and I will be presenting a paper “Developing a tool to help dog breeders predict genetic risks” at the OR Society’s Conference in September.

There are a growing number of DNA tests to help dog breeders identify potential breeding pairs that could be affected by inherited diseases.  In particular, Miniature Wirehaired Dachshunds known to suffer from a form of Epilepsy called Lafora Disease.  There are two different tests that have been used to determine if a Dachshund carries the autosomal recessive Lafora mutation, but not every dog is tested.  Consequently this creates 4 populations: tested; untested; clinically affected (i.e. showing symptoms) and clinically not affected.

As part of an OR Pro bono project an Excel tool was developed to evaluate the risk factors associated with the mutation status of DNA tested and untested dogs.   This presentation will explain the maths and probability theory that lies behind this problem and show how the tool was developed and can be used to help understand the risks of breeding affected puppies with and without the DNA test.

OR56 Annual Conference

9 – 11 September 2014

Royal Holloway University of London, Egham

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